BDBM50220296 1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-cyclopropylpiperidin-2-yl)cyclopropyl 4-(1-hydroxy-2-methylpropan-2-yl)piperazine-1-carboxylate::CHEMBL393941

SMILES CC(C)(CO)N1CCN(CC1)C(=O)OC1(CC1)[C@H]1CCC[C@@H](C2CC2)N1S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=QVNUOJRVQDGJQW-XZOQPEGZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50220296   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220296(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-cyclopropy...)
Affinity DataIC50:  12nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Lab.

Curated by ChEMBL
LigandPNGBDBM50220296(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-cyclopropy...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP3A4 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Lab.

Curated by ChEMBL
LigandPNGBDBM50220296(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-cyclopropy...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP3A4 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220296(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-cyclopropy...)
Affinity DataIC50:  39nMAssay Description:Inhibition of gamma-secretase assessed as reduction of cell Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed