BDBM50227982 (6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide::CHEMBL401870

SMILES CS(=O)(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C=C1)c1ccccc1)C(=O)NO

InChI Key InChIKey=RAJATBMMJHSJNJ-FQECFTEESA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50227982   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227982((6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-...)
Affinity DataIC50:  677nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227982((6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-...)
Affinity DataIC50:  93nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227982((6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-...)
Affinity DataIC50:  53nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227982((6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-...)
Affinity DataIC50:  51nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227982((6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-...)
Affinity DataIC50: >5.00E+3nMAssay Description:Binding affinity to MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227982((6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-...)
Affinity DataIC50: >5.00E+3nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed