BDBM50228744 5-Hydroxy-Diclofenac::CHEBI:59612

SMILES OC(=O)Cc1cc(O)ccc1Nc1c(Cl)cccc1Cl

InChI Key InChIKey=VNQURRWYKFZKJZ-UHFFFAOYSA-N

Data  5 KI  3 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50228744   

TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Rattus norvegicus (rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50228744(5-Hydroxy-Diclofenac | CHEBI:59612)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]HOCPCA from native CaMK2alpha in rat brain cortical membrane homogenates measured after 1 hr by TopCount scintillation counting m...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Rattus norvegicus (rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50228744(5-Hydroxy-Diclofenac | CHEBI:59612)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]NCS-382 from CaMK2alpha in rat brain cortical membrane homogenates measured after 1 hr by TopCount scintillation counting methodMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Rattus norvegicus (rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50228744(5-Hydroxy-Diclofenac | CHEBI:59612)
Affinity DataKi:  800nMAssay Description:Displacement of [3H]HOCPCA from recombinant rat CaMK2alpha expressed in HEK293T cells measured after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Rattus norvegicus (rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50228744(5-Hydroxy-Diclofenac | CHEBI:59612)
Affinity DataKi:  900nMAssay Description:Displacement of [3H]NCS-382 from CaMK2alpha in rat brain cerebral cortex membrane homogenates assessed as inhibition constant measured after 60 mins ...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Rattus norvegicus (rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50228744(5-Hydroxy-Diclofenac | CHEBI:59612)
Affinity DataKi:  900nMAssay Description:Displacement of [3H]NCS-382 from CaMK2alpha in rat brain cerebral cortex membrane homogenates assessed as inhibition constant measured after 60 mins ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50228744(5-Hydroxy-Diclofenac | CHEBI:59612)
Affinity DataIC50:  4.47E+5nMAssay Description:Inhibition of COX (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50228744(5-Hydroxy-Diclofenac | CHEBI:59612)
Affinity DataIC50:  1.81E+3nMAssay Description:Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as inhibition of intrinsic tryptophan fl...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1/2(Bos taurus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50228744(5-Hydroxy-Diclofenac | CHEBI:59612)
Affinity DataIC50:  4.47E+5nMAssay Description:In vitro inhibition of bovine prostaglandin G/H synthase, using bovine seminal vesicle microsomal preparations; IC50 in umol/LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed