BDBM50232534 5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine::CHEMBL251906

SMILES Nc1nc(N)c2c(COc3ccccc3F)cccc2n1

InChI Key InChIKey=HTKCHSHRTXOEIP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50232534   

TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232534(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232534(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232534(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: >3.00E+4nMAssay Description:Concentration required for the inhibition of acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed