BDBM50232790 CHEMBL4084542

SMILES C[C@H](NC(=O)c1c(CN2CCC(CC2)N2CCCCC2)c(nc2ccccc12)-c1cccc(c1)C(F)(F)F)c1ccccc1

InChI Key InChIKey=CPDKCWNAYYOWLG-VWLOTQADSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50232790   

TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50232790(CHEMBL4084542)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50232790(CHEMBL4084542)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Cav1.2 (unknown origin) by patchXpress electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50232790(CHEMBL4084542)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human ERG by patchXpress electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50232790(CHEMBL4084542)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of NK3 receptor (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50232790(CHEMBL4084542)
Affinity DataIC50:  80nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50232790(CHEMBL4084542)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin) by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50232790(CHEMBL4084542)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of NK2 receptor (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed