BDBM50233990 CHEMBL4104957

SMILES Nc1nc(O[C@H](c2ccc(Cl)cc2-c2ccccc2)C(F)(F)F)cc(n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1

InChI Key InChIKey=ZNSPHKJFQDEABI-NZQKXSOJSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50233990   

TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL

LigandBDBM50233990(CHEMBL4104957)Copy SMILESCopy InChI

Affinity DataIC50:  7nMAssay Description:Inhibition of TPH2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Karos Pharmaceuticals

Curated by ChEMBL

LigandBDBM50233990(CHEMBL4104957)Copy SMILESCopy InChI

Affinity DataIC50:  33nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI