BDBM50235922 CHEMBL4093614

SMILES Cl.Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1NC(=O)[C@H]1CCCN1

InChI Key InChIKey=NBVFGQHCNIZKKI-SKFKWQMISA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50235922   

TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50:  227nMAssay Description:Inhibition of human KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of microsomal CYP3A4 (unknown origin) using midazolam as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of microsomal CYP3A4 (unknown origin) using testosterone as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50:  1.77E+4nMAssay Description:Inhibition of microsomal CYP1A2 (unknown origin) using phenacetin as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50:  175nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of microsomal CYP2C8 (unknown origin) using amodiaquine as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of microsomal CYP2C9 (unknown origin) using diclofenac as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of microsomal CYP2C19 (unknown origin) using S-mephenytoin as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of microsomal CYP2D6 (unknown origin) using dextromethorphan as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50:  6.73E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by Qpatch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50235922(CHEMBL4093614)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of microsomal CYP2B6 (unknown origin) using bupropion as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed