BDBM50236228 CHEMBL4076035::US11186582, Example 6

SMILES Cc1cc([C@H]2CCCN(C2)C(=O)c2ccc3ccccc3c2)n2ncnc2n1

InChI Key InChIKey=TXIOKRWXRUIBEA-IBGZPJMESA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50236228   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM50236228(CHEMBL4076035 | US11186582, Example 6)
Affinity DataIC50: <100nMAssay Description:An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM50236228(CHEMBL4076035 | US11186582, Example 6)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair