BDBM50237125 CHEMBL4075766
SMILES Cc1ccc(cc1F)-c1ccc([nH]1)C(=O)NC(CN)c1ncc(CO)s1
InChI Key InChIKey=NRGUFSUZRVPWQZ-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50237125
TargetCytochrome P450 2C9(Homo sapiens (Human))
Lindsey F. Kimball Research Institute
Curated by ChEMBL
Lindsey F. Kimball Research Institute
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 60 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Lindsey F. Kimball Research Institute
Curated by ChEMBL
Lindsey F. Kimball Research Institute
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 60 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsey F. Kimball Research Institute
Curated by ChEMBL
Lindsey F. Kimball Research Institute
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Lindsey F. Kimball Research Institute
Curated by ChEMBL
Lindsey F. Kimball Research Institute
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair