BDBM50237605 Achromycin::Achromycin V::CHEBI:27902::Cyclopar::E701::Economycin::Liquamycin::Panmycin::Supramycin::Sustamycin::Tetrabid Organon::Tetracycline::Tetracyn::Vetquamycin

SMILES [H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C)C(=O)c1c(O)cccc1[C@@]3(C)O

InChI Key InChIKey=OFVLGDICTFRJMM-WESIUVDSSA-N

Data  9 IC50

PDB links: 16 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50237605   

TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50237605(Achromycin | Achromycin V | CHEBI:27902 | Cyclopar...)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50237605(Achromycin | Achromycin V | CHEBI:27902 | Cyclopar...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50237605(Achromycin | Achromycin V | CHEBI:27902 | Cyclopar...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50237605(Achromycin | Achromycin V | CHEBI:27902 | Cyclopar...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50237605(Achromycin | Achromycin V | CHEBI:27902 | Cyclopar...)
Affinity DataIC50:  6.06E+3nMAssay Description:Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
University Of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50237605(Achromycin | Achromycin V | CHEBI:27902 | Cyclopar...)
Affinity DataIC50:  1.57E+3nMAssay Description:Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 18 hrs by broth dilution assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Birla Institute Of Technology And Science

Curated by ChEMBL
LigandPNGBDBM50237605(Achromycin | Achromycin V | CHEBI:27902 | Cyclopar...)
Affinity DataIC50:  1.88E+5nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Birla Institute Of Technology And Science

Curated by ChEMBL
LigandPNGBDBM50237605(Achromycin | Achromycin V | CHEBI:27902 | Cyclopar...)
Affinity DataIC50:  2.04E+5nMAssay Description:Inhibition of HIV1 recombinant integrase 3'-processing activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50237605(Achromycin | Achromycin V | CHEBI:27902 | Cyclopar...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed