BDBM50238416 CHEMBL4087470

SMILES O=C(N1CCN(CC1)c1ncccn1)c1ccc(Nc2nc3ccccc3n3nnnc23)cc1

InChI Key InChIKey=KDDGVZUMYJMSJB-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50238416   

TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50: <5.01E+3nMAssay Description:Binding affinity to PARP16 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50: <5.01E+3nMAssay Description:Binding affinity to PARP1 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50: <5.01E+3nMAssay Description:Binding affinity to PARP2 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50: <5.01E+3nMAssay Description:Binding affinity to PARP4 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP11(Homo sapiens)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50: <5.01E+3nMAssay Description:Binding affinity to PARP11 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50:  20nMAssay Description:Inhibition of TNKS1 (unknown origin) expressed in HEK293 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in wnt3a ligand-induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50:  16nMAssay Description:Inhibition of His-tagged TNKS1 (1091 to 1325 residues) (unknown origin) assessed as reduction in PARsylation of GST-tev-Axin2 preincubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of human PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50: <5.01E+3nMAssay Description:Binding affinity to PARP14 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed