BDBM50238649 CHEMBL4103753

SMILES Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Cl)cc1Cl

InChI Key InChIKey=DDNCGNPWKAPRTO-UHFFFAOYSA-N

Data  4 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50238649   

TargetInterleukin-2(Homo sapiens (Human))
University Of Nantes

Curated by ChEMBL
LigandPNGBDBM50238649(CHEMBL4103753)
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to recombinant human IL-2 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-15(Homo sapiens)
University Of Nantes

Curated by ChEMBL
LigandPNGBDBM50238649(CHEMBL4103753)
Affinity DataKd:  1.91E+4nMAssay Description:Binding affinity to recombinant human IL-15 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-15(Homo sapiens)
University Of Nantes

Curated by ChEMBL
LigandPNGBDBM50238649(CHEMBL4103753)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to recombinant human IL-15 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
University Of Nantes

Curated by ChEMBL
LigandPNGBDBM50238649(CHEMBL4103753)
Affinity DataIC50:  350nMAssay Description:Inhibition of IL2-induced STAT3 phosphorylation in human NK92 cells incubated for 30 mins followed by IL-15 stimulation and measured after 1 hr by al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-15(Mus musculus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50238649(CHEMBL4103753)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of IL-15 in mouse 32Dbeta cells assessed as decrease in cell growth in presence of IL2 incubated for 30 mins followed by IL2 addition and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-15(Homo sapiens)
University Of Nantes

Curated by ChEMBL
LigandPNGBDBM50238649(CHEMBL4103753)
Affinity DataIC50:  190nMAssay Description:Inhibition of IL-15-induced STAT3 phosphorylation in human NK92 cells incubated for 30 mins followed by IL-15 stimulation and measured after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-15(Mus musculus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50238649(CHEMBL4103753)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of IL-15 in mouse 32Dbeta cells assessed as decrease in cell growth in presence of RLI incubated for 30 mins followed by RLI addition and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed