BDBM50239363 CHEMBL4094351

SMILES [H][C@]12C[C@@H](CO)N(C1)c1cc(Nc3cc4CCC(=O)Nc4c(OC\C=C\CO2)c3)n2ncc(C#N)c2n1

InChI Key InChIKey=SABLEOBBNNRHAD-WNJMFGOSSA-N

Data  6 IC50  2 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50239363   

TargetZinc finger and BTB domain-containing protein 16(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of GAL4 DNA binding domain fused PLZF BTB domain (unknown origin) expressed in HEK 293T/17 cells after 24 hrs by Bright-Glo luciferase cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of GAL4 DNA binding domain fused BCL6 BTB domain (unknown origin) expressed in HEK 293T/17 cells after 24 hrs by Bright-Glo luciferase cel...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to Mcl1 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha 3(Homo sapiens)
J. Uriach & Cia SA

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50:  640nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...More data for this Ligand-Target Pair
TargetB-cell lymphoma 6 protein(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataKd:  6.5nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...More data for this Ligand-Target Pair
TargetB-cell lymphoma 6 protein(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50:  2.90nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...More data for this Ligand-Target Pair
TargetB-cell lymphoma 6 protein(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...More data for this Ligand-Target Pair
TargetB-cell lymphoma 6 protein(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of Bcl6 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair