BDBM50239619 CHEMBL4087497

SMILES COC12CC3CC(C1)C(CC(=O)N1CC(O)C1)(C(C3)C2)c1ccc(F)cc1

InChI Key InChIKey=AVSPWVIWVZFZOT-UHFFFAOYSA-N

Data  2 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50239619   

Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239619(CHEMBL4087497)
Affinity DataIC50:  53nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239619(CHEMBL4087497)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239619(CHEMBL4087497)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair