BDBM50239782 CHEMBL4082113
SMILES COc1ccc2sc(cc2c1)C(=O)N(C)Cc1cccc(F)c1
InChI Key InChIKey=HHUOQHKKRABAQB-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50239782
Affinity DataIC50: 2.30nMAssay Description:Inhibition of recombinant GST-tagged mouse CLK4 using GRSRSRSRSRSR as substrate after 30 mins in presence of [gamma-32P]-ATP by scintillation countin...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant GST-tagged mouse CLK2 using GRSRSRSRSRSR as substrate after 30 mins in presence of [gamma-32P]-ATP by scintillation countin...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
German University In Cairo
Curated by ChEMBL
German University In Cairo
Curated by ChEMBL
Affinity DataIC50: 206nMAssay Description:Inhibition of full length recombinant GST-tagged human DYRK1B expressed in baculovirus using KKISGRLSPIMTEQ-NH2 as substrate after 15 minsMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1/CLK4(Homo sapiens (Human))
German University In Cairo
Curated by ChEMBL
German University In Cairo
Curated by ChEMBL
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of CLK1/4 in human T24 cells assessed as down regulation of HDAC1 expression after 3 days by Western blot analysisMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1/CLK4(Homo sapiens (Human))
German University In Cairo
Curated by ChEMBL
German University In Cairo
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CLK1/4 in human MDA-MB-231 cells assessed as down regulation of S6 kinase expression after 3 days by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human CLK4More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1/CLK4(Homo sapiens (Human))
German University In Cairo
Curated by ChEMBL
German University In Cairo
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CLK1/4 in human T24 cells assessed as down regulation of EGFR expression after 3 days by Western blot analysisMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1/CLK4(Homo sapiens (Human))
German University In Cairo
Curated by ChEMBL
German University In Cairo
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of CLK1/4 in human MDA-MB-231 cells assessed as down regulation of EGFR expression after 3 days by Western blot analysisMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo
Curated by ChEMBL
German University In Cairo
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human Dyrk1A expressed in Escherichia coli BL21 (DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant human GST-tagged Clk1 expressed in Escherichia coli using RS repeat substrate peptide after 15 mins in presence of [gamma-3...More data for this Ligand-Target Pair