BDBM50240512 7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one::CHEMBL52229::Osthol::osthole

SMILES [#6]-[#8]-c1ccc2ccc(=O)oc2c1-[#6]\[#6]=[#6](\[#6])-[#6]

InChI Key InChIKey=MBRLOUHOWLUMFF-UHFFFAOYSA-N

Data  7 IC50  1 EC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50240512   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Heinrich-Heine-UniversitäT DüSseldorf

Curated by ChEMBL
LigandPNGBDBM50240512(7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | ...)
Affinity DataIC50:  3.62E+4nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Heinrich-Heine-UniversitäT DüSseldorf

Curated by ChEMBL
LigandPNGBDBM50240512(7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | ...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Kinki University

Curated by ChEMBL
LigandPNGBDBM50240512(7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | ...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins by fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50240512(7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | ...)
Affinity DataEC50:  1.40E+4nMAssay Description:Positive allosteric modulation of human GABA-A alpha1beta2gamma2S receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase(Homo sapiens (Human))
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50240512(7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | ...)
Affinity DataIC50:  2.09E+5nMAssay Description:Inhibitory concentration against glyceraldehyde-3-phosphate dehydrogenase was determined as log 1/IC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM50240512(7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | ...)
Affinity DataIC50:  5.25E+4nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediatelyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM50240512(7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | ...)
Affinity DataIC50:  8.11E+4nMAssay Description:Antagonistic potency for NK-3 receptor was determined in vitro using isolated rat portal vein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExportin-1(Homo sapiens (Human))
Osaka University

Curated by ChEMBL
LigandPNGBDBM50240512(7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | ...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of CRM1-mediated hemagglutinin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed