BDBM50240671 (5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydro-1H-imidazol-2-yl)-amine::CHEMBL1079::TIZANIDINE::Zanaflex

SMILES Clc1ccc2nsnc2c1NC1=NCCN1

InChI Key InChIKey=XFYDIVBRZNQMJC-UHFFFAOYSA-N

Data  4 KI  5 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50240671   

TargetNischarin(Homo sapiens (Human))
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50240671((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
Affinity DataKi:  28nMAssay Description:Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2ARMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50240671((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
Affinity DataKi:  62nMMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50240671((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
Affinity DataKi:  75nMMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(NEONATAL RAT)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50240671((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
Affinity DataKi:  76nMMore data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50240671((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50240671((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50240671((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50240671((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50240671((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair