BDBM50240911 4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-isothiazole::4-(4-Fluorophenyl)-5-(4-(methylsulfonyl)phenyl)isothiazole::CHEMBL171646

SMILES CS(=O)(=O)c1ccc(cc1)-c1sncc1-c1ccc(F)cc1

InChI Key InChIKey=RTLNMGAQEOBANE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50240911   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240911(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-i...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240911(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-i...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240911(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-i...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of COX2 in LPS-stimulated human bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50240911(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-i...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed