BDBM50242740 CHEMBL459850::N-(3-(7-Amino-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide::Type II inhibitor, 14
SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
InChI Key InChIKey=ZWVLMQTXUWMUII-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50242740
Affinity DataIC50: 11nMpH: 7.5Assay Description:An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate.More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of ACK1 (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataEC50: 77nMAssay Description:Inhibition of Ret by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of Ron by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Inhibition of PDGFRalpha by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Inhibition of Bmx by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Inhibition of EphA3 by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Inhibition of EphB4 by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Inhibition of FGFR1 by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 236nMAssay Description:Inhibition of Flt1 by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:Inhibition of KDR by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Inhibition of c-Kit by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Inhibition of Lck by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Inhibition of PDGFRbeta by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Inhibition of Src by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 71nMAssay Description:Inhibition of Syk by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Inhibition of TrkC by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of FLT3 by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of InsR by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of NTRK1More data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of Tyk2 by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of ZAP70 by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of Met by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of ALK by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Inhibition of Tie2 by cellular assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Korea University
Curated by ChEMBL
Korea University
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMpH: 7.5Assay Description:An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester...More data for this Ligand-Target Pair