BDBM50243216 CHEMBL443661::N,N-dimethyl-2-(4-(6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidin-2-yl)piperazin-1-yl)ethanamine

SMILES CN(C)CCN1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1

InChI Key InChIKey=UGXRNXXGEXPELZ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50243216   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243216(CHEMBL443661 | N,N-dimethyl-2-(4-(6-phenyl-7-(4-((...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Akt1 (unknown origin) phosphorylation in human by C33a cells by IPKA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243216(CHEMBL443661 | N,N-dimethyl-2-(4-(6-phenyl-7-(4-((...)
Affinity DataIC50:  39nMAssay Description:Inhibition of Akt2 (unknown origin) phosphorylation in human by C33a cells by IPKA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243216(CHEMBL443661 | N,N-dimethyl-2-(4-(6-phenyl-7-(4-((...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Akt1 (unknown origin) phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243216(CHEMBL443661 | N,N-dimethyl-2-(4-(6-phenyl-7-(4-((...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Akt2 (unknown origin) phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243216(CHEMBL443661 | N,N-dimethyl-2-(4-(6-phenyl-7-(4-((...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human ERG in embryonic kidney cells by radioligand-binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243216(CHEMBL443661 | N,N-dimethyl-2-(4-(6-phenyl-7-(4-((...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Akt1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243216(CHEMBL443661 | N,N-dimethyl-2-(4-(6-phenyl-7-(4-((...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Akt1 (unknown origin) by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243216(CHEMBL443661 | N,N-dimethyl-2-(4-(6-phenyl-7-(4-((...)
Affinity DataIC50:  39nMAssay Description:Inhibition of Akt2 (unknown origin) by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243216(CHEMBL443661 | N,N-dimethyl-2-(4-(6-phenyl-7-(4-((...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Akt2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed