BDBM50243977 4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-trimethoxyphenyl)-1,5-dihydro-2H-pyrrole-2-one::CHEMBL453336

SMILES COc1cc(cc(OC)c1OC)C1=C(CNC1=O)c1cn(COCc2ccccc2)c2ccccc12

InChI Key InChIKey=PRGQUWCDXPFMCG-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50243977   

TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant VEGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of human recombinant EPHB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of human recombinant ERBB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human recombinant FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  9.30E+4nMAssay Description:Inhibition of human recombinant CK2A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of human recombinant SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human recombinant VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of human recombinant FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human recombinant TIE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243977(4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-t...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human recombinant IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed