BDBM50244953 CHEMBL4063500

SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc2n1C1CCCC1

InChI Key InChIKey=JWILUIVAYLRFIY-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50244953   

TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  53nMAssay Description:Inhibition of recombinant human full length C-terminal 6His-tagged CaMKK2 expressed in baculovirus infected sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  43nMAssay Description:Binding affinity towards [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in HG108-15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  19nMAssay Description:Binding affinity towards [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in HG108-15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  31nMAssay Description:Binding affinity towards [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in HG108-15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human full length C-terminal 6His-tagged Aurora-A expressed in baculovirus infected sf21 cells using kemptide substrate in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  9nMAssay Description:Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  8.80nMAssay Description:Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  44nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged LIMK1 (285 to 638 residues) expressed in baculovirus infected sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TAO2(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  84nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged TAO2 expressed in sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C/Inner centromere protein(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged Aurora-C (35-end residues)/N-terminal GST-tagged INCENP (821-end residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed