BDBM50245464 CHEBI:52646::LEPTOMYCIN B

SMILES CC\C(\C=C\[C@@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(\C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O

InChI Key InChIKey=YACHGFWEQXFSBS-XYERBDPFSA-N

Data  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50245464   

TargetExportin-1(Homo sapiens (Human))
Georg-August-University G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50245464(CHEBI:52646 | LEPTOMYCIN B)
Affinity DataIC50:  151nMAssay Description:Inhibition of fluorescently labeled PKI phi(0)Leu NES binding to human CRM1 expressed in Escherichia coli BL21 (DE3) by fluorescence polarization com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExportin-1(Homo sapiens (Human))
Georg-August-University G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50245464(CHEBI:52646 | LEPTOMYCIN B)
Affinity DataIC50:  1nMAssay Description:Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed