BDBM50245586 CHEMBL4077123

SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1cc(Nc2ccc(C(=O)N3CCOCC3)c(NC(=O)C=C)c2)c(=O)n(C)c1

InChI Key InChIKey=UBXBHXGYYBYXOB-UHFFFAOYSA-N

Data  1 KI  4 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50245586   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50245586(CHEMBL4077123)
Affinity DataKi:  8.90nMAssay Description:Reversible inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells using poly (Glu,T...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50245586(CHEMBL4077123)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK3 (781 to end residues) expressed in baculovirus infected Sf9 insect cells using poly (Glu,T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50245586(CHEMBL4077123)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged BMX expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr)4:1 as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50245586(CHEMBL4077123)
Affinity DataEC50: <30nMAssay Description:Inhibition of BTK auto-phosphorylation at Y223 in human Pfeiffer cells measured after 4 hrs by chemiluminescent assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50245586(CHEMBL4077123)
Affinity DataEC50:  4.70nMAssay Description:Irreversible inhibition of recombinant full length wild-type 3'-FLAG-tagged BTK (unknown origin) expressed in HEK293T cells assessed as reduction in ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50245586(CHEMBL4077123)
Affinity DataIC50:  7nMAssay Description:Inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr)4:1 as s...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50245586(CHEMBL4077123)
Affinity DataEC50: <30nMAssay Description:Inhibition of BTK auto-phosphorylation at Y223 in human U2932 cells measured after 4 hrs by chemiluminescent assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50245586(CHEMBL4077123)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged wild-type EGFR (695 to end residues) expressed in baculovirus infected Sf9 insect cells using p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed