BDBM50247054 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methylnicotinamide::CHEMBL517140::GSK-189254
SMILES CNC(=O)c1ccc(Oc2ccc3CCN(CCc3c2)C2CCC2)nc1
InChI Key InChIKey=WROHEWWOCPRMIA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50247054
Affinity DataKi: 0.120nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.126nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Displacement of [3H]-N-R-methylhistamine from human H3 receptor isolated from C6 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.676nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from rat histamine H3 receptor expressed in HEK293 cells after 45 mins by liquid scintillation spectromet...More data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
Affinity DataKi: >2.51E+3nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >3.16E+3nMAssay Description:Binding affinity to human histamine H2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.550nMAssay Description:Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...More data for this Ligand-Target Pair