BDBM50247634 CHEMBL4067973

SMILES N[C@@H](CCCN(CCc1cccc(c1)C(N)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O

InChI Key InChIKey=HSCPXDPGPWYINM-NMNPZVDOSA-N

Data  2 KI  6 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50247634   

TargetNicotinamide N-methyltransferase(Homo sapiens (Human))
Biokin

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataKi:  89nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
TargetNicotinamide N-methyltransferase(Homo sapiens (Human))
Biokin

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataKi:  89nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of DOT1L (unknown origin) after 1 hr by filter-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of PRMT7 (unknown origin) using [3H]-SAM as co-factor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA 5'-monophosphate methyltransferase(Homo sapiens)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of BCDIN3D (unknown origin) using [3H]-SAM as co-factor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide N-methyltransferase(Homo sapiens (Human))
Biokin

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataIC50:  4.36E+3nMAssay Description:Inhibition of wild-type human full length NNMT expressed in Escherichia coli BL21(DE3) cells assessed as reduction in 1-methyl-nicotinamide formation...More data for this Ligand-Target Pair
TargetNicotinamide N-methyltransferase(Homo sapiens (Human))
Biokin

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
TargetNicotinamide N-methyltransferase(Homo sapiens (Human))
Biokin

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) using nicotinamide/SAM as substrate/co-factor measured for 20 m...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50247634(CHEMBL4067973)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of SMYD2 (unknown origin) using [3H]-SAM as co-factor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed