BDBM50248258 3-(2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide::CHEMBL474350::US10201527, Compound 24::US10736881, Compound 24::US8551988, 24

SMILES OCCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)C1CCCCC1

InChI Key InChIKey=HVPLNZBXZZVRRY-CSKARUKUSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50248258   

TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248258(3-(2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzo[d]imi...)
Affinity DataIC50:  203nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248258(3-(2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzo[d]imi...)
Affinity DataIC50:  3.24E+3nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248258(3-(2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzo[d]imi...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of recombinant HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248258(3-(2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzo[d]imi...)
Affinity DataIC50:  203nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248258(3-(2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzo[d]imi...)
Affinity DataIC50:  203nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248258(3-(2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzo[d]imi...)
Affinity DataIC50:  3.24E+3nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248258(3-(2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzo[d]imi...)
Affinity DataIC50:  3.24E+3nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent