BDBM50248375 CHEMBL491688::N-hydroxy-3-(2-phenethyl-1-(3,4,5-trimethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acrylamide::US10201527, Compound 2::US10736881, Compound 2::US8551988, 2

SMILES COc1cc(Cn2c(CCc3ccccc3)nc3cc(\C=C\C(=O)NO)ccc23)cc(OC)c1OC

InChI Key InChIKey=QXYMMOVSPDCPIX-SDNWHVSQSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50248375   

TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248375(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Affinity DataIC50:  355nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248375(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Affinity DataIC50:  26nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248375(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Affinity DataIC50:  47nMAssay Description:Inhibition of recombinant HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248375(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Affinity DataIC50:  355nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248375(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Affinity DataIC50:  355nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H3.1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248375(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Affinity DataEC50:  1.70E+3nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248375(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Affinity DataIC50:  26nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248375(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Affinity DataIC50:  26nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent