BDBM50248376 3-(1-ethyl-2-phenethyl-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide::CHEMBL490721::US10201527, Compound 38::US10736881, Compound 38

SMILES CCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12

InChI Key InChIKey=KLSHPXPMJUGIDY-JLHYYAGUSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50248376   

TargetHistone deacetylase 1(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248376(3-(1-ethyl-2-phenethyl-1H-benzo[d]imidazol-5-yl)-N...)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248376(3-(1-ethyl-2-phenethyl-1H-benzo[d]imidazol-5-yl)-N...)
Affinity DataIC50:  218nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248376(3-(1-ethyl-2-phenethyl-1H-benzo[d]imidazol-5-yl)-N...)
Affinity DataIC50:  148nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248376(3-(1-ethyl-2-phenethyl-1H-benzo[d]imidazol-5-yl)-N...)
Affinity DataIC50:  218nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248376(3-(1-ethyl-2-phenethyl-1H-benzo[d]imidazol-5-yl)-N...)
Affinity DataIC50:  148nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent