BDBM50248414 CHEMBL522785::N4-(3-(benzo[d]thiazol-2-yl)phenyl)-6,7-dimethoxy-N2-(5-methyl-1H-pyrazol-3-yl)quinazoline-2,4-diamine

SMILES COc1cc2nc(Nc3cc(C)n[nH]3)nc(Nc3cccc(c3)-c3nc4ccccc4s3)c2cc1OC

InChI Key InChIKey=GEPKFPGFWUHVLZ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50248414   

TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of VEGFR3 by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50:  940nMAssay Description:Inhibition of insulin receptor by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora B by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of PDGFRbeta by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50:  960nMAssay Description:Inhibition of Src by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50:  780nMAssay Description:Inhibition of EphB4 by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of TIE2 by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of EGFR by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of VEGFR2 by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50:  810nMAssay Description:Inhibition of IGF1R by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248414(CHEMBL522785 | N4-(3-(benzo[d]thiazol-2-yl)phenyl)...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of Aurora A by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed