BDBM50248427 1,1,1-trifluoro-2-(4-((R)-2-methyl-4-(2-(pyridin-3-yl)ethyl)piperazin-1-ylsulfonyl)phenyl)propan-2-ol::CHEMBL523444

SMILES C[C@@H]1CN(CCc2cccnc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F

InChI Key InChIKey=CHXVGBDXNRZKOE-QRIPLOBPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50248427   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50248427(1,1,1-trifluoro-2-(4-((R)-2-methyl-4-(2-(pyridin-3...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50248427(1,1,1-trifluoro-2-(4-((R)-2-methyl-4-(2-(pyridin-3...)
Affinity DataIC50:  29nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed