BDBM50248464 CHEMBL491677::N-[4-(isoindolin-2-yl)phenyl]-6',7'-dimethoxyquinazolin-4'-amine

SMILES COc1cc2ncnc(Nc3ccc(cc3)N3Cc4ccccc4C3)c2cc1OC

InChI Key InChIKey=YDFSDWFVXLJPNL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50248464   

TargetAurora kinase B(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248464(CHEMBL491677 | N-[4-(isoindolin-2-yl)phenyl]-6',7'...)
Affinity DataIC50:  920nMAssay Description:Inhibition of Aurora B by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248464(CHEMBL491677 | N-[4-(isoindolin-2-yl)phenyl]-6',7'...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of insulin receptor by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248464(CHEMBL491677 | N-[4-(isoindolin-2-yl)phenyl]-6',7'...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of Aurora A by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248464(CHEMBL491677 | N-[4-(isoindolin-2-yl)phenyl]-6',7'...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of IGF1R by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248464(CHEMBL491677 | N-[4-(isoindolin-2-yl)phenyl]-6',7'...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of CDK4 by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50248464(CHEMBL491677 | N-[4-(isoindolin-2-yl)phenyl]-6',7'...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of EGFR by virtual HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed