BDBM50248469 2-(4-((R)-4-(2,2-difluoro-2-(pyridin-4-yl)ethyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)-1,1,1-trifluoropropan-2-ol::CHEMBL491489

SMILES C[C@@H]1CN(CC(F)(F)c2ccncc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F

InChI Key InChIKey=ZSIVBDKHGVHTKM-NYRJJRHWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50248469   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50248469(2-(4-((R)-4-(2,2-difluoro-2-(pyridin-4-yl)ethyl)-2...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50248469(2-(4-((R)-4-(2,2-difluoro-2-(pyridin-4-yl)ethyl)-2...)
Affinity DataIC50:  33nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed