BDBM50248662 CHEMBL4091345
SMILES NC(=O)c1sc(Oc2cccnc2)c-2c1CCc1cnsc-21
InChI Key InChIKey=PNSCLJRKJNHORL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50248662
Affinity DataEC50: 3nMAssay Description:Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot methodMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair