BDBM50248936 CHEMBL4083922::US10981896, Compound 25

SMILES CNC(=O)c1ccc2NC(=O)\C(=C(/Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)c2c1

InChI Key InChIKey=JWSARCOTGLCHON-ZIADKAODSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248936   

TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248936(CHEMBL4083922 | US10981896, Compound 25)
Affinity DataKi:  2.30nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248936(CHEMBL4083922 | US10981896, Compound 25)
Affinity DataIC50:  18nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248936(CHEMBL4083922 | US10981896, Compound 25)
Affinity DataIC50:  67nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248936(CHEMBL4083922 | US10981896, Compound 25)
Affinity DataIC50:  18nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed