BDBM50249580 Azeliragon::PF-04494700::TTP448::US11524942, Compound I

SMILES CCCCc1nc(cn1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCCN(CC)CC)cc1

InChI Key InChIKey=KJNNWYBAOPXVJY-UHFFFAOYSA-N

Data  3 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50249580   

TargetAdvanced glycosylation end product-specific receptor(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50249580(Azeliragon | PF-04494700 | TTP448 | US11524942, Co...)
Affinity DataKd:  500nMAssay Description:Inhibition of amyloid beta (1 to 42) binding to RAGE domain V (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdvanced glycosylation end product-specific receptor(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50249580(Azeliragon | PF-04494700 | TTP448 | US11524942, Co...)
Affinity DataKd:  12.7nMAssay Description:The binding affinity of COMPOUND I and compounds of the invention to human sRAGE (the soluble extracellular domain of the human receptor for advanced...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50249580(Azeliragon | PF-04494700 | TTP448 | US11524942, Co...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of hERG transfected in CHO cells by manual patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdvanced glycosylation end product-specific receptor(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50249580(Azeliragon | PF-04494700 | TTP448 | US11524942, Co...)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of biotinylated human RAGE/amyloid beta interaction incubated for 120 mins by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50249580(Azeliragon | PF-04494700 | TTP448 | US11524942, Co...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of SERT (unknown origin) expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdvanced glycosylation end product-specific receptor(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50249580(Azeliragon | PF-04494700 | TTP448 | US11524942, Co...)
Affinity DataKd:  13nMAssay Description:Binding affinity to recombinant human RAGE assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed