BDBM50250108 CHEMBL4096573

SMILES OC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1cnn2c(O)cc(nc12)-c1ccccc1

InChI Key InChIKey=PHGTYMRDHDEHLI-HIFRSBDPSA-N

Data  2 IC50  3 Kd

PDB links: 2 PDB IDs match this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50250108   

TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Binding affinity to human cGAS assessed as dissociation constantMore data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Binding affinity to human Cyclic GMP-AMP synthase (2 to 522 residues) expressed in Sf9 cells by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair