BDBM50250242 CHEMBL4068781

SMILES COC(=O)c1cccc(NC(=O)CCOc2ccc(cc2)C(C)(C)CC(C)(C)C)c1

InChI Key InChIKey=FLLJXWXMLLAKKZ-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50250242   

TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250242(CHEMBL4068781)
Affinity DataKi:  740nMAssay Description:Competitive inhibition of human MDH1 expressed in Escherichia coli using oxaloacetic acid as substrate in presence of NADH after 30 mins by double re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250242(CHEMBL4068781)
Affinity DataKi:  950nMAssay Description:Inhibition of human MDH1 expressed in Escherichia coli after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250242(CHEMBL4068781)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of HIF-1alpha in human HCT116 cells incubated for 12 hrs under hypoxic conditions by HRE dual-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250242(CHEMBL4068781)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of human MDH1 expressed in Escherichia coli after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250242(CHEMBL4068781)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of human MDH2 after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed