BDBM50250297 CHEMBL4083481

SMILES COc1cc(CN2CCC(CC2)NC(=O)c2ccc(Cl)cc2Cl)cc(OC)c1

InChI Key InChIKey=ZHPMKYPXJOGYRU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50250297   

TargetSodium- and chloride-dependent GABA transporter 2(Mus musculus)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250297(CHEMBL4083481)
Affinity DataIC50:  1.20E+6nMAssay Description:Inhibition of mouse GAT2 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250297(CHEMBL4083481)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250297(CHEMBL4083481)
Affinity DataIC50:  6.46E+5nMAssay Description:Inhibition of mouse GAT3 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mus musculus)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250297(CHEMBL4083481)
Affinity DataIC50:  1.20E+6nMAssay Description:Inhibition of mouse BGT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250297(CHEMBL4083481)
Affinity DataIC50:  6.40E+5nMAssay Description:Inhibition of human BGT1/human GAT3 chimera D expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent betaine transporter(Mus musculus)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250297(CHEMBL4083481)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of mouse BGT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent betaine transporter(Mus musculus)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250297(CHEMBL4083481)
Affinity DataIC50:  3.02E+4nMAssay Description:Inhibition of mouse BGT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed