BDBM50250399 5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl}-5H-furan-2-one::5-Hydroxy-4-{6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl}-5H-furan-2-one::CHEMBL463914::manoalide

SMILES C\C(CCC1=C(C)CCCC1(C)C)=C/CCC1=CC[C@@H](O[C@H]1O)C1=CC(=O)O[C@H]1O

InChI Key InChIKey=FGJIDQWRRLDGDB-CPIXEKRISA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50250399   

TargetPhospholipase A2(Honeybee)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibitory activity against bee secretory Phospholipase A2 enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2(Honeybee)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 40nMAssay Description:Inhibition of bee venom PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 816nMAssay Description:Concentration required for in vitro inhibitory activity against human type II phospholipase A2More data for this Ligand-Target Pair
In DepthDetails Article

TargetPhospholipase A2(Honeybee)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 6.25E+4nMAssay Description:Inhibition of bee venom group3 sPLA2 at 10 uM by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2, membrane associated(Rat)
Istituto Per La Chimica Di Molecole Di Interesse Biologico Cnr

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 3.84E+4nMAssay Description:Inhibition of rat air pouch group2 sPLA2 at 10 uM by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Istituto Per La Chimica Di Molecole Di Interesse Biologico Cnr

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 9.32E+4nMAssay Description:Inhibition of human synovial group2 sPLA2 at 10 uM by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human synovial secretory PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2(Honeybee)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of bee venom secretory PLA2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions prei...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition mea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Istituto Per La Chimica Di Molecole Di Interesse Biologico Cnr

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibitory activity against human synovial recombinant Phospholipase enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcidic phospholipase A2 2(Indian cobra)
Istituto Per La Chimica Di Molecole Di Interesse Biologico Cnr

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of Naja naja venom group1 sPLA2 at 10 uM by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Istituto Per La Chimica Di Molecole Di Interesse Biologico Cnr

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 1.50E+6nMAssay Description:In vitro inhibition of human recombinant secretory Phospholipase A2 (group II).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2, membrane associated(Rat)
Istituto Per La Chimica Di Molecole Di Interesse Biologico Cnr

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 2.00E+6nMAssay Description:In vitro inhibition of rat secretory Phospholipase A2 (group II).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2(Honeybee)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 500nMAssay Description:Inhibition of bee venom phospholipase A2 after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2(Honeybee)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 500nMAssay Description:Inhibition of bee venom phospholipase A2 after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcidic phospholipase A2 beta(Eastern diamondback rattlesnake)
Umr 5154 Cnrs

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Crotalus adamanteus venom phospholipase A2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2(Honeybee)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of bee venom group 3 secretory phospholipase A2 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Istituto Per La Chimica Di Molecole Di Interesse Biologico Cnr

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human synovial recombinant group 2 secretory phospholipase A2 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2(Honeybee)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of bee venom group3 sPLA2 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Istituto Per La Chimica Di Molecole Di Interesse Biologico Cnr

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human synovial group2 sPLA2 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed