BDBM50250863 CHEMBL4062760

SMILES OC(=O)c1ccc2nc(sc2c1)N1CCC(CC1)OCc1c(onc1-c1ccccc1OC(F)(F)F)C1CC1

InChI Key InChIKey=RPJGOVWDLAWXIW-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50250863   

TargetBile acid receptor(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50250863(CHEMBL4062760)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50250863(CHEMBL4062760)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human GST-tagged FXR LBD (193 to 472 residues) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBile acid receptor(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50250863(CHEMBL4062760)
Affinity DataEC50:  19nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed