BDBM50252244 (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-{[3-(4-methylpiperazin-1-yl)phenyl]sulfonyl}piperazine::CHEMBL481313

SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cccc(c1)N1CCN(C)CC1)c1ccc(F)cc1C(F)(F)F

InChI Key InChIKey=PFQSNLMKOAZFJQ-QGZVFWFLSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50252244   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50252244((2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-meth...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human 11betaHSD1 expressed in CHO cells by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50252244((2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-meth...)
Affinity DataIC50:  42nMAssay Description:Inhibition of rat 11betaHSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50252244((2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-meth...)
Affinity DataIC50:  28nMAssay Description:Inhibition of C57BL/6 mouse 11betaHSD1 in presence of human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50252244((2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-meth...)
Affinity DataIC50:  12nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cells by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed