BDBM50252711 3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-fluoropiperidin-4-yl]methyl}benzamide::CHEMBL493677

SMILES CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1

InChI Key InChIKey=HQZBFDAIHIKVRO-CXAGYDPISA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50252711   

TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human T-type Cav3.1 expressed in HEK293 cells at -80mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50:  62nMAssay Description:Inhibition of human T-type Cav3.3 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50: <20nMAssay Description:Inhibition of sigma1 opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50:  1.49E+4nMAssay Description:Inhibition of human L-type Cav1.2 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50:  32nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50:  44nMAssay Description:Inhibition of T-type calcium channel alpha1I by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of 5HT4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human T-type Cav3.1 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50:  4.11E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed