BDBM50254324 CHEMBL512298::N2-(2,6-dichlorophenyl)-N7-(4-isopropylphenyl)thiazolo[5,4-d]pyrimidine-2,7-diamine

SMILES CC(C)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1

InChI Key InChIKey=GHAKCJRTZFIKPR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50254324   

TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254324(CHEMBL512298 | N2-(2,6-dichlorophenyl)-N7-(4-isopr...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254324(CHEMBL512298 | N2-(2,6-dichlorophenyl)-N7-(4-isopr...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed