BDBM50254513 5-amino-N-(2-((N-ethyl-2,6-difluorobenzamido)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide::CHEMBL467633

SMILES CCN(CC(O)(CNC(=O)c1cnn(c1N)-c1ccc(F)cc1)C(F)(F)F)C(=O)c1c(F)cccc1F

InChI Key InChIKey=PEUFWNJXEBOKMU-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50254513   

TargetCytochrome P450 1A2(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254513(5-amino-N-(2-((N-ethyl-2,6-difluorobenzamido)methy...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254513(5-amino-N-(2-((N-ethyl-2,6-difluorobenzamido)methy...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254513(5-amino-N-(2-((N-ethyl-2,6-difluorobenzamido)methy...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254513(5-amino-N-(2-((N-ethyl-2,6-difluorobenzamido)methy...)
Affinity DataIC50:  7.94nMAssay Description:Displacement of fluorescent labelled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254513(5-amino-N-(2-((N-ethyl-2,6-difluorobenzamido)methy...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254513(5-amino-N-(2-((N-ethyl-2,6-difluorobenzamido)methy...)
Affinity DataEC50:  7.94nMAssay Description:Agonist activity at human glucocorticoid receptor in human A549 cells assessed as transcriptional activity by MMTV luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254513(5-amino-N-(2-((N-ethyl-2,6-difluorobenzamido)methy...)
Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed