BDBM50254590 CHEMBL449546::N,N-dibutyl-4-chloro-5-methyl-1-(4-(2-phenylacetamido)-2-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-1H-pyrazole-3-carboxamide

SMILES CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(NC(=O)Cc2ccccc2)cc1C(=O)N1CCc2ccccc2C1

InChI Key InChIKey=MEFONFJTPZVJTA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50254590   

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254590(CHEMBL449546 | N,N-dibutyl-4-chloro-5-methyl-1-(4-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of GST fused Bcl-2 (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254590(CHEMBL449546 | N,N-dibutyl-4-chloro-5-methyl-1-(4-...)
Affinity DataIC50:  2.37E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254590(CHEMBL449546 | N,N-dibutyl-4-chloro-5-methyl-1-(4-...)
Affinity DataIC50:  270nMAssay Description:Inhibition of GST fused Bcl-2 (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed