BDBM50254593 1-[2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-4-(2-oxo-2-phenyl-ethoxy)-phenyl]-5-methyl-1H-pyrazole-3-carboxylic acid dibutylamide::CHEMBL509208

SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(OCC(=O)c2ccccc2)cc1C(=O)N1CCc2ccccc2C1

InChI Key InChIKey=XIOUWKRWZBNVPX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50254593   

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254593(1-[2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-4-(2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of GST fused Bcl-2 (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254593(1-[2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-4-(2...)
Affinity DataIC50:  3.24E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254593(1-[2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-4-(2...)
Affinity DataIC50:  330nMAssay Description:Inhibition of GST fused Bcl-2 (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed