BDBM50254712 CHEMBL499468::N-((1S,2R)-1-Benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(1,1-dioxo-1lambda*6*-[1,2]thiazinan-2-yl)-N'-((R)-1-phenyl-ethyl)-isophthalamide

SMILES C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)N1CCCCS1(=O)=O)c1ccccc1

InChI Key InChIKey=BQAAFVLWSABVAL-YYSPBGNDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50254712   

TargetBeta-secretase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50254712(CHEMBL499468 | N-((1S,2R)-1-Benzyl-3-cyclopropylam...)
Affinity DataIC50:  251nMAssay Description:Inhibition of BACE2 expressed in human 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50254712(CHEMBL499468 | N-((1S,2R)-1-Benzyl-3-cyclopropylam...)
Affinity DataIC50:  158nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in human 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed