BDBM50255420 4-(4-chloro-2-fluorophenylamino)-6,7-dimethoxyquinoline-3-carboxamide::CHEMBL479845

SMILES COc1cc2ncc(C(N)=O)c(Nc3ccc(Cl)cc3F)c2cc1OC

InChI Key InChIKey=SSSQBBWJMZYDLU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50255420   

TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255420(4-(4-chloro-2-fluorophenylamino)-6,7-dimethoxyquin...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50255420(4-(4-chloro-2-fluorophenylamino)-6,7-dimethoxyquin...)
Affinity DataIC50:  18nMAssay Description:Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed