BDBM50256260 CHEMBL4094403
SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC[C@H](C)NC(=O)[C@H]2CSCc3cc(CSC[C@H](NC1=O)C(O)=O)cc(CSC[C@H](NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N2)c3
InChI Key InChIKey=NWSILYZBKZBZOH-SOPRAFLKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50256260
Affinity DataKi: 0.360nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Inhibition of recombinant mouse C-terminal 6His-tagged plasma kallikrein (20 to 638 residues) using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrat...More data for this Ligand-Target Pair
Affinity DataKi: 510nMAssay Description:Inhibition of pig plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged KLK2 (1 to 261 residues) expressed in mouse NS0 cells using fluorogenic PFR-AMC peptide as su...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of Abl tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged KLK5 (67 to 293 residues) expressed in mouse NS0 cells using fluorogenic Boc-VPR-AMC peptide ...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human activated protein C by fluorescence based assayMore data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
Bicycle Therapeutics
Curated by ChEMBL
Bicycle Therapeutics
Curated by ChEMBL
Affinity DataKi: 5.00E+4nMAssay Description:Inhibition of recombinant human N-terminal 6His-tagged matriptase catalytic domain (596 to 855 residues) expressed in Escherichia coli using fluoroge...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged complement component C1s (1 to 688 residues) expressed in mouse NS0 cells using fluorogenic Z-...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human Granzyme B (21 to 247 residues) using fluorogenic Ac-IEPD-pNA peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human factor 12a using fluorogenic peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human C-terminal polyHis-tagged KLK13 (1 to 262 residues) expressed in HEK293 cells using fluorogenic Boc-VPR-AMC peptide a...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of chimeric PDGF receptor with FLT-3 cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human PDE4B1 expressed in African green monkey COS7 cells using cAMP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human plasma kallikrein spiked in pig vitreous using HMWK as substrate assessed as suppression of bradykinin release preincubated for 1...More data for this Ligand-Target Pair